QUANTITATION OF GENTAMICIN SULFATE IN INJECTABLE SOLUTIONS BY CAPILLARY ELECTROPHORESIS

被引：45

作者：

FLURER, CL

WOLNIK, KA

机构：

[1] National Forensic Chemistry Center, US Food and Drug Administration, Cincinnati, OH 45202

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 663卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)85253-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The results presented in this communication establish the use of capillary electrophoresis as a tool in the analysis of injectable solutions containing the antibiotic complex gentamicin sulfate. The utilization of a berate buffer leads to the separation of the individual components and their visualization by direct UV detection. This rapid and straightforward procedure yields qualitative and quantitative information simultaneously, and could be utilized as an alternative to the multiple assays required by current US Pharmacopeia protocols.

引用

页码：259 / 263

页数：5

共 10 条

[1]

ACKERMANS MT, 1992, J CHROMATOGR, V606, P229

[2] DETERMINATION OF SALBUTAMOL-RELATED IMPURITIES BY CAPILLARY ELECTROPHORESIS [J].