PEPTIDE-INDUCED ANTIVIRAL PROTECTION BY CYTOTOXIC T-CELLS

被引:239
作者
SCHULZ, M
ZINKERNAGEL, RM
HENGARTNER, H
机构
[1] Institute of Pathology, University Hospital
关键词
VACCINATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; T-CELL EPITOPE;
D O I
10.1073/pnas.88.3.991
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A specific antiviral cytotoxic immune response in vivo could be induced by the subcutaneous injection of the T-cell epitope of the lymphocytic choriomeningitis virus (LCMV) nucleoprotein as an unmodified free synthetic peptide (Arg-Pro-Gln-Ala-Ser-Gly-Val-Tyr-Met-Gly-Asn-Leu-Thr-Ala-Gln) emulsified in incomplete Freund's adjuvant. This immunization rendered mice into a LCMV-specific protective state as shown by the inhibition of LCMV replication in spleens of such mice. The protection level of these mice correlated with the ability to respond to the peptide challenge by CD8+ virus-specific cytotoxic T cells. This is a direct demonstration that peptide vaccines can be antivirally protective in vivo, thus encouraging further search for appropriate mixtures of stable peptides that may be used as T-cell vaccines.
引用
收藏
页码:991 / 993
页数:3
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