ONCOGENICITY BY METHYL METHANESULFONATE IN MALE RF MICE

被引：36

作者：

CLAPP, NK

CRAIG, AW

TOYA, RE

机构：

[1] Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN

[2] Paterson Laboratories, Christie Hospital and Holt Radium Institute

来源：

SCIENCE | 1968年 / 161卷 / 3844期

关键词：

D O I：

10.1126/science.161.3844.913

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The incidences of lung tumors and thymic lymphomas were increased in young adult male RF mice receiving 30 milligrams of methyl methanesulfonate per kilogram of body weight daily in the drinking water throughout life. Differences in oncogenicity between treatment with methyl methanesulfonate and with dimethylnitrosamine or diethylnitrosamine suggest a qualitative difference between the site (or sites) of alkylation by methyl methanesulfonate and by dimethylnitrosamine or diethylnitrosamine within the nucleic acids.

引用

页码：913 / &

共 18 条

[1] ALKYLATING AGENTS [J].