BIOACTIVE CONFORMATION OF LUTEINIZING-HORMONE-RELEASING HORMONE - EVIDENCE FROM A CONFORMATIONALLY CONSTRAINED ANALOG

被引:301
作者
FREIDINGER, RM [1 ]
VEBER, DF [1 ]
PERLOW, DS [1 ]
BROOKS, JR [1 ]
SAPERSTEIN, R [1 ]
机构
[1] MERCK INST THERAPEUT RES,RAHWAY,NJ 07065
关键词
D O I
10.1126/science.7001627
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:656 / 658
页数:3
相关论文
共 26 条
[1]   STEREOSPECIFIC CONVERSION OF PEPTIDES INTO BETA-LACTAMS [J].
BALDWIN, JE ;
AU, A ;
CHRISTIE, M ;
HABER, SB ;
HESSON, D .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (20) :5957-5958
[2]  
BLAKE CA, 1972, P SOC EXP BIOL MED, V141, P1100, DOI 10.3181/00379727-141-36942
[3]   CONFORMATIONAL ANALOGY BETWEEN BETA-LACTAM ANTIBIOTICS AND TETRAHEDRAL TRANSITION-STATES OF A DIPEPTIDE [J].
BOYD, DB .
JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (05) :533-537
[4]   CONFORMATION OF LL AND LD HAIRPIN BENDS WITH INTERNAL HYDROGEN-BONDS IN PROTEINS AND PEPTIDES [J].
CHANDRASEKARAN, R ;
LAKSHMINARAYANAN, AV ;
PANDYA, UV ;
RAMACHANDRAN, GN .
BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 303 (01) :14-27
[5]   BETA-TURNS IN PROTEINS [J].
CHOU, PY ;
FASMAN, GD .
JOURNAL OF MOLECULAR BIOLOGY, 1977, 115 (02) :135-175
[6]   WHY CYCLIC PEPTIDES - COMPLEMENTARY APPROACHES TO CONFORMATIONS [J].
DEBER, CM ;
MADISON, V ;
BLOUT, ER .
ACCOUNTS OF CHEMICAL RESEARCH, 1976, 9 (03) :106-113
[7]  
FREIDINGER RM, 1979, PEPTIDES STRUCTURE B, P703
[8]  
FREIDINGER RM, UNPUBLISHED
[9]  
GROSS E, 1962, J BIOL CHEM, V237, P1856
[10]   3-DIMENSIONAL MOLECULAR MODELING AND DRUG DESIGN [J].
GUND, P ;
ANDOSE, JD ;
RHODES, JB ;
SMITH, GM .
SCIENCE, 1980, 208 (4451) :1425-1431