A NEW HUMAN HLA CLASS-II-RELATED LOCUS, DM

被引：251

作者：

KELLY, AP ^{[1
]}

MONACO, JJ ^{[1
]}

CHO, SG ^{[1
]}

TROWSDALE, J ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MICROBIOL & IMMUNOL,RICHMOND,VA 23298

来源：

NATURE | 1991年 / 353卷 / 6344期

关键词：

D O I：

10.1038/353571a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

HLA CLASS II molecules have a crucial role in the immune response to antigens. We have isolated two new class II-like complementary DNA sequences, RING6 and RING7, which map between the HLA-DNA and -DOB loci. They are novel members of the immunoglobulin gene family which may have diverged before the duplications that gave rise to the main class II loci. The RING6 and RING7 genes seem to encode alpha- and beta-chains of a previously undiscovered class II-related protein.

引用

页码：571 / 573

页数：3

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