SYNTHESIS OF RAC-THREO AND RAC-ERYTHRO-ALPHA-(2,2-DICHLOROACETAMIDO)-BETA-HYDROXY-PARA-NITROHYDROCINNAMALDEHYDE

被引：0

作者：

ZANETTI, G

VOGLER, K

机构：

[1] Chemische Forschungsabteilung, F Hoffmann-La Roche & Co, Basel

来源：

HELVETICA CHIMICA ACTA | 1969年 / 52卷 / 04期

关键词：

D O I：

10.1002/hlca.19690520407

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

rac‐threo‐α‐(2, 2‐Dichloroacetamido)‐β‐hydroxy‐p‐nitrohydrocinnamaldehyde 3 and rac‐erythro‐α‐(2, 2‐dichloroacetamido)‐β‐hydroxy‐p‐nitrohydrocinnamaldehyde 4 were synthesized starting from α‐acetamido‐p‐nitroacetophenone 7, and their structures were proved bn− reduction to rac‐chloramphenicol 19 and rac‐erythro‐2‐(2, 2‐dichloroacetamido)‐1‐(p‐nitrophenyl)v 1, 3‐propanediol 14 respectively. 3 exhibited only low antibacterial activity compared to rac‐chloramphenicol 19. Copyright © 1969 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：907 / &

共 7 条

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[2] *D,L-DESOXY-CHLOROMYCETIN - D,L-3-P-NITROPHENYL-2-DICHLORACETAMIDO-PROPANOL-1
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[3] CHLORAMPHENICOL (CHLOROMYCETIN) .7. SYNTHESIS THROUGH PARA-NITROACETOPHENONE
LONG, LM
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1949, 71 (07) : 2473 - 2475
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[5] SYNTHESIS OF NUCLEOSIDE-5' ALDEHYDES
PFITZNER, KE
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (19) : 3027 - &
[6] ZANETTI G, 1968, CHIMIA, V22, P494
[7] 1954, Patent No. 708703

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