A medical elaboration on von Willebrand disease with its dental management

Objective: von Willebrand disease (vWD) is the most common type of autosomally inherited bleeding disorder representing a range of quantitative and qualitative pathologies of the adhesive glycoprotein, von Willebrand factor (vWF). Since symptoms are often mild, a significant majority of patients remain undiagnosed. Method: A review from the literature which imparts the knowledge on background, pathophysiology, classification, diagnostic measures and treatment modalities of this fatal bleeding disorder. Results: With all forms of vWD, however, bleeding episodes can be severe and may require treatment. Conclusions: A primary care physician should play a role in recognizing the signs and symptoms of vWD and in referring patients for proper management. The treatment of bleeding in vWD involves the use of desmopressin and plasma-derived vWF concentrates and a variety of adjunctive agents. (C) 2016 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.(star)