EFFECT OF FATS HIGH IN INDIVIDUAL SATURATED FATTY-ACIDS ON PLASMA LIPOPROTEIN[A] LEVELS IN YOUNG HEALTHY-MEN

被引：0

作者：

THOLSTRUP, T ^{[1
]}

MARCKMANN, P ^{[1
]}

VESSBY, B ^{[1
]}

SANDSTROM, B ^{[1
]}

机构：

[1] UNIV UPPSALA,DEPT GERIATR,S-75105 UPPSALA,SWEDEN

来源：

JOURNAL OF LIPID RESEARCH | 1995年 / 36卷 / 07期

关键词：

STEARIC ACID; PALMITIC ACID; MYRISTIC ACID; T-PA ACTIVITY; LDL CHOLESTEROL;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma lipoprotein[a] (Lp[a]) is associated with atherogenesis and thrombogenesis. We examined how plasma Lp[a] in healthy young men was affected by fats high in stearic (C18), palmitic (C16), and lauric + myristic (C12 + C14) acid (experiment I, 15 subjects), and by fats high in myristic (C14) and palmitic (C16) acid (experiment II, 12 subjects). Strictly controlled isocaloric diets with 36% of energy from test fats were served in random order for 3 weeks separated by wash-out period(s). Diets high in C18 gave significantly higher levels of Lp[a] (51(12-560) mg/L) than diets high in C16 (38(12-533 mg/L) (P = 0.020) and C12 + C14 (34(12-534) mg/L) (P = 0.002). These differences were observed in several of the subjects in experiment I. In experiment II we saw no difference in plasma Lp[a] after diets high in C16 and C14. Our observations suggest that a fat high in stearic acid might affect Lp[a] in a different way than fats high in palmitic and myristic + lauric acid. Lp[a] concentrations were not associated with changes in tissue-plasminogen activator (t-PA) activity, factor VII coagualant activity, or plasma LDL cholesterol.

引用

页码：1447 / 1452

页数：6