LIPOXYGENASE INHIBITION AND ANTIOXIDANT PROPERTIES OF PROTOBERBERINE AND APORPHINE ALKALOIDS ISOLATED FROM MAHONIA-AQUIFOLIUM

被引：65

作者：

MISIK, V

BEZAKOVA, L

MALEKOVA, L

KOSTALOVA, D

机构：

[1] SLOVAK ACAD SCI,INST EXPTL PHARMACOL,BRATISLAVA 84216,SLOVAKIA

[2] COMENIUS UNIV BRATISLAVA,FAC PHARM,DEPT CELLULAR & MOLEC BIOL DRUGS,BRATISLAVA 83232,SLOVAKIA

[3] COMENIUS UNIV BRATISLAVA,FAC PHARM,DEPT PHARMACOGNOSY & BOT,BRATISLAVA 83232,SLOVAKIA

来源：

PLANTA MEDICA | 1995年 / 61卷 / 04期

关键词：

D O I：

10.1055/s-2006-958107

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Products of lipoxygenase metabolism play a role in the pathogenesis of psoriasis. Four protoberberine alkaloids, berberine, oxyberberine, jatrorrhizine, columbamine, and two aporphine alkaloids, magnoflorine, and corytuberine, isolated from Mahonia aquifolium, were tested for lipoxygenase inhibition. Oxyberberine, corytuberine, and columbamine were the most potent lipoxygenase inhibitors tested, whereas berberine and magnoflorine exhibited only low potencies. A strong linear correlation (r = 0.866) between lipoxygenase inhibition and lipid antioxidant properties of these compounds was found. These data suggest that the mechanism of lipoxygenase inhibition by these alkaloids may be linked to the inhibition of lipids hydroperoxide substrate accumulation. Inhibition of lipoxygenase by these compounds may contribute to the therapeutic effect of M. aquifolium extracts in the treatment of psoriasis.

引用

页码：372 / 373

页数：2

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