ENZYMATIC RESOLUTION OF 2-HYDROXY-4-PHENYLBUTANOIC ACID AND 2-HYDROXY-4-PHENYLBUTENOIC ACID

被引：50

作者：

CHADHA, A

MANOHAR, M

机构：

[1] SPIC Pharma R and D Center Maraimalai Nagar

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 03期

关键词：

D O I：

10.1016/0957-4166(95)00051-P

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Racemic 2-hydroxy-4-phenylbutanoic acid and 2-hydroxy-4-phenyl-butenoic acid have been resolved using a lipase. In each ease, the (R)-2-hydroxy and the (S)-2-acetoxy acids were isolated with high enantiomeric excess and yield.

引用

页码：651 / 652

页数：2

共 14 条

[1]

ATWOOD MR, 1986, J CHEM SOC P1, P1011

[2] BLUEPRINT FOR A LIPASE SUPPORT - USE OF HYDROPHOBIC CONTROLLED-PORE GLASSES AS MODEL SYSTEMS [J].

BOSLEY, JA ;

CLAYTON, JC .

BIOTECHNOLOGY AND BIOENGINEERING, 1994, 43 (10) :934-938

[3] LIPASE-CATALYZED IRREVERSIBLE TRANSESTERIFICATION USING ENOL ESTERS - XAD-8 IMMOBILIZED LIPOPROTEIN LIPASE-CATALYZED RESOLUTION OF SECONDARY ALCOHOLS [J].

HSU, SH ;

WU, SS ;

WANG, YF ;

WONG, CH .

TETRAHEDRON LETTERS, 1990, 31 (44) :6403-6406

[4] KINETIC RESOLUTION OF 2-SUBSTITUTED ESTERS CATALYZED BY A LIPASE EX PSEUDOMONAS-FLUORESCENS [J].

KALARITIS, P ;

REGENYE, RW ;

PARTRIDGE, JJ ;

COFFEN, DL .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (03) :812-815

[5] IMMOBILIZED ENZYMES - LEARNING FROM PAST SUCCESSES AND FAILURES [J].

KATCHALSKIKATZIR, E .

TRENDS IN BIOTECHNOLOGY, 1993, 11 (11) :471-478

[6]

LAWTON G, 1989, Patent No. 4757069

[7]

MALEATA FX, 1991, BIOTECHNOL BIOENG, V38, P853

[8] H-1 AND H-2 NUCLEAR MAGNETIC-RESONANCE DETERMINATION OF THE ENANTIOMERIC PURITY AND ABSOLUTE-CONFIGURATION OF ALPHA-DEUTERIATED PRIMARY CARBOXYLIC-ACIDS, ALCOHOLS, AND AMINES [J].

PARKER, D .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1983, (01) :83-88

[9]

SCHMIDT E, 1992, NATO ADV SCI I C-MAT, V381, P377

[10] POLYFUNCTIONAL (R)-2-HYDROXYCARBOXYLIC ACIDS BY REDUCTION OF 2-OXO ACIDS WITH HYDROGEN GAS OR FORMATE AND RESTING CELLS OF PROTEUS-VULGARIS [J].

SCHUMMER, A ;

YU, H ;

SIMON, H .

TETRAHEDRON, 1991, 47 (43) :9019-9034

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