EFFECT OF ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS ON CILIARY ACTIVITY

被引：1

作者：

JIAN, L ^{[1
]}

PO, ALW ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,SCH PHARM,CTR MED BIOL,DRUG DELIVERY RES GRP,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 107卷 / 01期

关键词：

ANGIOTENSIN-CONVERTING ENZYME; ENZYME INHIBITOR; CAPTOPRIL; ENALAPRIL; LISINOPRIL; CILIA;

D O I：

10.1016/0378-5173(94)90304-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of three angiotensin-converting enzyme (ACE) inhibitors on ciliary beat frequency was monitored with a view to investigating whether ciliotoxicity could account for the high incidence of cough associated with the use of those agents. An additional objective was to investigate whether intranasal administration of those ACE inhibitors was safe. It was found that captopril and enalapril maleate reduced ciliary beat frequency in a dose-dependent manner. The effect of captopril was reversible while that of enalapril maleate was not. Lisinopril was non-ciliotoxic at four concentrations up to 113 mM.

引用

页码：77 / 81

页数：5

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