FAILURE OF TIME-KILL SYNERGY STUDIES USING SUBINHIBITORY ANTIMICROBIAL CONCENTRATIONS TO PREDICT IN-VIVO ANTAGONISM OF CEPHALOSPORIN-RIFAMPIN COMBINATIONS AGAINST STAPHYLOCOCCUS-AUREUS

被引：11

作者：

BRANDT, CM ^{[1
]}

ROUSE, MS ^{[1
]}

TALLAN, BM ^{[1
]}

WILSON, WR ^{[1
]}

STECKELBERG, JM ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DIV INFECT DIS,INFECT DIS RES LAB,ROCHESTER,MN 55905

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 09期

关键词：

D O I：

10.1128/AAC.38.9.2191

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Results of in vitro time-kill synergy studies using subinhibitory, inhibitory, or suprainhibitory concentrations of bactericidal agents were compared with treatment outcomes of experimental infective endocarditis due to a methicillin-susceptible strain of Staphylococcus aureus. For rifampin-cephalosporin combinations, in vitro synergy testing using recommended fractions of the MIC failed to predict antagonism in vivo while concentrations above the MIC corresponded with antagonism in vivo.

引用

页码：2191 / 2193

页数：3

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