FIRST SYNTHESES OF NOVEL PACLITAXEL(TAXOL) ANALOGS MODIFIED AT THE C4-POSITION

被引：40

作者：

CHEN, SH ^{[1
]}

KADOW, JF ^{[1
]}

FARINA, V ^{[1
]}

FAIRCHILD, CR ^{[1
]}

JOHNSTON, KA ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 21期

关键词：

D O I：

10.1021/jo00100a011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regiospecific method for the modification of paclitaxel at the C-4 position has been invented, as exemplified by the synthesis of the C-4 cyclopropyl ester of paclitaxel (4) and the C-4 benzoate of paclitaxel (5).

引用

页码：6156 / 6158

页数：3

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