LESSONS FROM LETHAL ALBINO MICE

被引：13
作者：
KELSEY, G [1 ]
SCHUTZ, G [1 ]
机构：
[1] GERMAN CANC RES CTR, W-6900 HEIDELBERG 1, GERMANY
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 02期
关键词：
D O I：
10.1016/0959-437X(93)90032-K
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Results from the analysis of mice homozygous for lethal albino deletions suggested the existence of a locus involved in the regulation of gene expression in the liver. The surprising finding that the locus encodes an enzyme active in tyrosine metabolism forces us to re-evaluate the lethal albino phenotype and advises caution in the interpretation of seemingly simple phenotypes.
引用
收藏
页码：259 / 264
页数：6
相关论文
共 39 条
[1]   ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].
CAPECCHI, MR .
SCIENCE, 1989, 244 (4910) :1288-1292
[2]   THE GLUCOCORTICOID HORMONE SIGNAL TRANSDUCTION PATHWAY IN MICE HOMOZYGOUS FOR CHROMOSOMAL DELETIONS CAUSING FAILURE OF CELL TYPE-SPECIFIC INDUCIBLE GENE-EXPRESSION [J].
DEFRANCO, D ;
BALI, D ;
TORRES, R ;
DEPINHO, RA ;
ERICKSON, RP ;
GLUECKSOHNWAELSCH, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (13) :5607-5610
[3]   METALLOTHIONEIN MESSENGER-RNA EXPRESSION IN MICE HOMOZYGOUS FOR CHROMOSOMAL DELETIONS AROUND THE ALBINO LOCUS [J].
DEFRANCO, D ;
MORRIS, SM ;
LEONARD, CM ;
GLUECKSOHNWAELSCH, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1161-1164
[4]   GLUCOSE-6-PHOSPHATASE DEFICIENCY CAUSED BY RADIATION-INDUCED ALLELES AT ALBINO LOCUS IN MOUSE [J].
ERICKSON, RP ;
GLUECKSO.S ;
CORI, CF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 59 (02) :437-&
[5]   MAMMALIAN GENES COORDINATELY REGULATED BY GROWTH ARREST SIGNALS AND DNA-DAMAGING AGENTS [J].
FORNACE, AJ ;
NEBERT, DW ;
HOLLANDER, MC ;
LUETHY, JD ;
PAPATHANASIOU, M ;
FARGNOLI, J ;
HOLBROOK, NJ .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (10) :4196-4203
[6]   2 ADJACENT AP-1-LIKE BINDING-SITES FORM THE ELECTROPHILE-RESPONSIVE ELEMENT OF THE MURINE GLUTATHIONE-S-TRANSFERASE YA SUBUNIT GENE [J].
FRILING, RS ;
BERGELSON, S ;
DANIEL, V .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (02) :668-672
[7]   LETHAL CHROMOSOMAL DELETIONS IN THE MOUSE, A MODEL SYSTEM FOR THE STUDY OF DEVELOPMENT AND REGULATION OF POSTNATAL GENE-EXPRESSION [J].
GLUECKSOHNWAELSCH, S ;
DEFRANCO, D .
BIOESSAYS, 1991, 13 (11) :557-561
[8]   GENETIC-CONTROL OF MORPHOGENETIC AND BIOCHEMICAL DIFFERENTIATION - LETHAL ALBINO DELETIONS IN THE MOUSE [J].
GLUECKSOHNWAELSCH, S .
CELL, 1979, 16 (02) :225-237
[9]  
GOLDSMITH LA, 1989, METABOLIC BASIS INHE, P547
[10]   DECREASED HNF-1 GENE-EXPRESSION IN MICE HOMOZYGOUS FOR A 1.2-CENTIMORGAN DELETION ON CHROMOSOME-7 [J].
GONZALEZ, FJ ;
LIU, SY ;
KOZAK, CA ;
NEBERT, DW .
DNA AND CELL BIOLOGY, 1990, 9 (10) :771-776
1234