ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese

被引：14

作者：

Sun, Chengjun ^{[1
]}

Wei, Haiyan ^{[2
]}

Chen, Xiuli ^{[3
]}

Zhao, Zhuhui ^{[1
]}

Du, Hongwei ^{[4
]}

Song, Wenhui ^{[5
]}

Yang, Yu ^{[6
]}

Zhang, Miaoying ^{[1
]}

Lu, Wei ^{[1
]}

Pei, Zhou ^{[1
]}

Xi, Li ^{[1
]}

Yang, Jian ^{[7
]}

Zhi, Dijing ^{[1
]}

Cheng, Ruoqian ^{[1
]}

Luo, Feihong ^{[1
]}

机构：

[1] Fudan Univ, Childrens Hosp, Dept Pediat Endocrinol & Inherited Metab Dis, Shanghai, Peoples R China

[2] Childrens Hosp Zhengzhou, Dept Pediat Endocrinol, Zhengzhou, Henan, Peoples R China

[3] Soochow Univ, Affiliated Childrens Hosp, Dept Pediat Endocrinol, Suzhou, Jiangsu, Peoples R China

[4] Jilin Univ, Affiliated Hosp 1, Dept Pediat Endocrinol, Changchun, Jilin, Peoples R China

[5] Childrens Hosp Shanxi Prov, Dept Pediat Endocrinol, Taiyuan, Shanxi, Peoples R China

[6] Childrens Hosp Jiangxi Prov, Dept Pediat Endocrinol, Nanchang, Jiangxi, Peoples R China

[7] Karolinska Inst, Sci Life Ctr, Dept Biosci & Nutr, Stockholm, Sweden

来源：

META GENE | 2016年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Type; 1; diabetes; Genetic association; Single nucleotide polymorphism; ERBB3;

D O I：

10.1016/j.mgene.2016.05.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Type 1 diabetes (T1D) is an autoimmune disease that has strong contribution of genetic factors to its etiology. We aimed to assess the genetic association between non-HLA genes and T1D in a Chinese case-control cohort recruited from multiple centers consisting of 364 patients with T1D and 719 unrelated healthy children. We genotyped 55 single nucleotide polymorphisms (SNP) markers located in 16 non-HLA genes (VTCN1, PTPN22, CTLA4, SUMO4, CD274, IL2RA, INS, DHCR7, ERBB3, VDR, CYP27B1, CD69, CD276, PTPN2, UBASH3A, and IL2RB) using SNaPshot multiple single-base extension methods. After multivariate analysis and correction for multiple comparisons, we identified the SNP rs2292239 in ERBB3 gene were significantly associated with T1D. The frequency of the major G allele was significantly decreased in patients with T1D (68.8% in T1D vs 77.3% in controls, OR 0.65, 95% CI 0.53-0.79, P = 0.02), and the minor allele T was associated with an increased risk of T1D (OR 1.55, 95% CI 1.26-1.90, P = 0.02). Our haplotype analysis confirmed that rs2292239 was the primary T1D association locus in our current investigation. These results indicated that the ERBB3-rs2292239 was the primary T1D association locus among the investigated 55 SNPs in 16 non-HLA genes in Chinese Han population. (C) 2016 The Authors. Published by Elsevier B.V.

引用

页码：120 / 123

页数：4

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