Resistance to fucidic acid in clinical Staphylococcus aureus isolates

被引：0

作者：

Celen, Mustafa Kemal ^{[1
]}

Ayaz, Celal ^{[1
]}

Ozmen, Esen ^{[1
]}

Geyik, M. Faruk ^{[1
]}

Hosoglu, Salih ^{[1
]}

机构：

[1] Dicle Univ, Tip Fak, Infeks Hastaliklari & Klin Mikrobiyol Anabilim Da, Diyarbakir, Turkey

来源：

KLIMIK JOURNAL | 2005年 / 18卷 / 03期

关键词：

Staphylococcus aureus; fusidic acid; MRSA; MSSA;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fusidic acid derived from Fusidium coccineum is an antibiotic which inhibites protein synthesis of bacteria and has been used in Turkey since the beginning of 1998. In vitro activity of fusidic acid was investigated in 69 methicillin-resistant Staphylococcus aureus (MRSA) and 56 methicillin-sensitive S. aureus (MSSA) isolates by disk diffusion method. Fusidic acid resistance was found 20.3 % in MRSA strains and 3.6 % in MSSA strains by disk diffusion test. In our country fusidic acid preserves its state of being an empirical antimicrobial agent in a combination therapy by its lower resistance rates and it is a preferred peroral drug in middle and mild staphylococcal infections of outpatient clinics.

引用

页码：114 / 116

页数：3

共 29 条

[1]

Altun B, 1998, 28 TURK MIKR K 4 9 E, P12

[2]

[Anonymous], 1996, PATHOL BIOL, V44, P1

[3]

Bengisun JS, 1998, 28 TURK MIKR K 4 9 E, P12

[4]

Cavusoglu C., 1998, Infeksiyon Dergisi = Turkish Journal of Infection, V12, P467

[5] Resistance of staphylococci in The Netherlands: surveillance by an electronic network during 1989-1995 [J].

de Neeling, AJ ;

van Leeuwen, WJ ;

Schouls, LM ;

Schot, CS ;

van Veen-Rutgers, A ;

Beunders, AJ ;

Buiting, AGM ;

Hol, C ;

Ligtvoet, EEJ ;

Petit, PL ;

Sabbe, LJM ;

van Griethuysen, AJA ;

van Embden, JDA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (01) :93-101

[6]

Diler M, 1998, 28 TURK MIKR K 4 9 E, P12

[7] FUSIDIC ACID ALONE OR IN COMBINATION WITH VANCOMYCIN FOR THERAPY OF EXPERIMENTAL ENDOCARDITIS DUE TO METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS [J].

FANTIN, B ;

LECLERCQ, R ;

DUVAL, J ;

CARBON, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (11) :2466-2469

[8]

Franklin TJ, 1971, BIOCH ANTIMICROBIAL, P105

[9] Emergence, mechanism, and clinical implications of reduced glycopeptide susceptibility in Staphylococcus aureus [J].

Geisel, R ;

Schmitz, FJ ;

Fluit, AC ;

Labischinski, H .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2001, 20 (10) :685-697

[10]

Guleroglu S., 2002, ANKEM DERG, V16, P457

← 1 2 3 →