REDUCTIVE CYCLIZATION OF ESTER-CONTAINING ENYNES WITH A PRACTICAL TITANOCENE REAGENT - SYNTHESIS OF BICYCLIC CYCLOPENTENONES AND IMINOCYCLOPENTENES

被引：86

作者：

GROSSMAN, RB ^{[1
]}

BUCHWALD, SL ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 22期

关键词：

D O I：

10.1021/jo00048a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of Cp2TiCl2 with 2 equiv of EtMgBr provides an effective reagent for the reductive cyclization of enynes, including ester-containing enynes, to bicyclic titanacyclopentenes. These metallacycles may then be transformed into bicyclic cyclopentenones or iminocyclopentenes in good yields by reaction with CO or an isocyanide, respectively.

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页码：5803 / 5805

页数：3

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