EVIDENCE FOR A HYPERGLYCEMIA-DEPENDENT DECREASE OF ANTITHROMBIN-III-THROMBIN COMPLEX-FORMATION IN HUMANS

被引：44
|
作者：
CERIELLO, A
GIUGLIANO, D
QUATRARO, A
MARCHI, E
BARBANTI, M
LEFEBVRE, P
机构：
[1] NAPLES UNIV,FAC SHINAGAWA KU,CATTEDRA DIABETOL & DIETOTERAPIA,I-80138 NAPLES,ITALY
[2] CASA CURA SAN RITA,CTR DIABETOL,TARANTO,ITALY
[3] ALFA RIC,BOLOGNA,ITALY
[4] STATE UNIV LIEGE,DIV DIABET NUTR & METAB DISORDERS,B-4000 LIEGE,BELGIUM
来源：
DIABETOLOGIA | 1990年 / 33卷 / 03期
关键词：
Antithrombin III activity; fibrinopeptide A; hyperglycaemia; thrombin hyperactivity; thrombin-antithrombin III complex;
D O I：
10.1007/BF00404044
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus. © 1990 Springer-Verlag.
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页码：163 / 167
页数：5
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