EFFECTS OF IONIZING-RADIATIONS ON A PHARMACEUTICAL COMPOUND, CHLORAMPHENICOL

被引：29

作者：

VARSHNEY, L

PATEL, KM

机构：

[1] ISOMED, I AND IPO, Board of Radiation/Isotope Techn., Bombay 400085, India

来源：

RADIATION PHYSICS AND CHEMISTRY | 1994年 / 43卷 / 05期

关键词：

D O I：

10.1016/0969-806X(94)90064-7

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Chloramphenicol, a broad spectrum antibiotic, has been irradiated using Cobalt-60 gamma radiation and electron beam at graded radiation doses upto 100 kGy. Several degradation products and free radicals are formed on irradiation. Purity, degradation products, free radicals, discolouration, crystallinity, solubility and entropy of radiation processing have been investigated. Aqueous solutions undergo extensive radiolysis even at low doses. Physico-chemical, microbiological and toxicological tests do not show significant degradation at sterilization dose. High performance liquid chromatography (HPLC), differential scanning calorimetry (DSC), UV-spectrophotometry, diffuse reflectance spectroscopy (DRS) and electron spin resonance spectroscopy (ESR) techniques were employed for the investigations.

引用

页码：471 / 480

页数：10

共 15 条

[1] RADIATION STERILIZATION OF PHARMACEUTICALS AND POLYMERS [J].

GOPAL, NGS .

RADIATION PHYSICS AND CHEMISTRY, 1978, 12 (1-2) :35-50

[2] A SPECTROPHOTOMETRIC READOUT METHOD FOR FREE-RADICAL DOSIMETRY [J].

GUPTA, BL ;

BHAT, RM ;

NARAYAN, GR ;

NILEKANI, SR .

RADIATION PHYSICS AND CHEMISTRY, 1985, 26 (06) :647-656

[3]

HOWEL FN, 1975, STANDARD METHODS CHE, P745

[4]

IRVING SN, 1984, DANGEROUS PROPERTIES

[5] A REVIEW - RADIATION STERILIZATION OF PHARMACEUTICALS [J].

JACOBS, GP .

RADIATION PHYSICS AND CHEMISTRY, 1985, 26 (02) :133-142

[6]

PATEL KM, 1986, THESIS BOMBAY U INDI

[7]

VARSHNEY L, 1988, INDIAN PHARM C CALCU

[8]

VARSHNEY L, 1990, THESIS U BOMBAY INDI

[9]

Varshney L., 1989, INDIAN J PHARM SCI, V51, P25

[10]

VARSHNEY L, 1989, RADIO CHEM RAD CHEM

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