A RECEPTOR FOR INTERLEUKIN-10 IS RELATED TO INTERFERON RECEPTORS

被引：209

作者：

HO, ASY ^{[1
]}

LIU, Y ^{[1
]}

KHAN, TA ^{[1
]}

HSU, DH ^{[1
]}

BAZAN, JF ^{[1
]}

MOORE, KW ^{[1
]}

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC,MOLEC & CELLULAR BIOL RES INST,DEPT MOLEC BIOL,PALO ALTO,CA 94304

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 23期

关键词：

CYTOKINE RECEPTORS; BA; F3-CELLS;

D O I：

10.1073/pnas.90.23.11267

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an almost-equal-to 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell line (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (almost-equal-to 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship is interaction of IL-10R and IFN-gammaR or their signaling pathways.

引用

页码：11267 / 11271

页数：5