Comparison of the effectiveness of lidocaine and salbutamol on coughing provoked by intravenous remifentanil during anesthesia induction

被引：11

作者：

Bang, Si-Ra ^{[2
]}

Ahn, Hyun Joo ^{[1
]}

Kim, Hyo Jin ^{[1
]}

Kim, Gunn Hee ^{[3
]}

Kim, Jie Ae ^{[1
]}

Yang, Mikyung ^{[1
]}

Kim, Jin-Kyoung ^{[1
]}

Cho, Hyun-Sung ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Anesthesiol & Pain Med, Irwon Dong, Seoul 135710, South Korea

[2] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea

[3] Natl Med Ctr, Seoul, South Korea

来源：

KOREAN JOURNAL OF ANESTHESIOLOGY | 2010年 / 59卷 / 05期

关键词：

Cough; Lidocaine; Remifentanil; Salbutamol;

D O I：

10.4097/kjae.2010.59.5.319

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Background: Coughing is a side effect of opioids that is rarely studied. Here, we evaluated the incidence of remifentanil induced coughing during anesthesia induction in an attempt to identify its risk factors and to examine the preventive effects of lidocaine and salbutamol. Methods: A total of 237 patients scheduled to undergo general anesthesia were allocated randomly into three groups. Group C received no medication, while Group L received 2% lidocaine at 0.5 mg/kg intravenously 1 minute prior to remifentanil infusion and Group S inhaled one metered aerosol puff of salbutamol 15 minutes prior to entering the operating room. Remifentanil was infused at 5 ng/ml by target controlled infusion and coughing was measured for five minutes and graded as none, mild, moderate, or severe based on the number of coughs. Results: The incidences of coughing were 30.4%, 25.3%, and 35.4% in Groups C, L, and S, respectively. The incidences, onset times, and severity of coughing did not differ significantly among groups. In addition, multivariate analysis showed that non-smoking and a lower body weight were risk factors of remifentanil-induced coughing (odds ratio, 8.13; P = 0.024, 1.11, and 0.004, respectively). Conclusions: The incidence of remifentanil-induced coughing was 30%. A total of 0.5 mg/kg lidocaine and 1 metered aerosol puff of salbutamol did not prevent coughing. Non-smoking and low body weight were found to be risk factors of remifentanil-induced coughing.

引用

页码：319 / 322

页数：4

共 19 条

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