THE COMPLETE NUCLEOTIDE-SEQUENCE OF A PATHOGENIC MOLECULAR CLONE OF SIMIAN IMMUNODEFICIENCY VIRUS

被引：332

作者：

REGIER, DA ^{[1
]}

DESROSIERS, RC ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 11期

关键词：

D O I：

10.1089/aid.1990.6.1221

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIVmac239, has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is 10,279 base pairs in length and contains open reading frames for gag, pol, vif, vpr, vpx, tat, rev, and env. The nef gene contains an in-frame premature stop after the 92nd codon. At the nucleotide level, SIVmac239 is closely related to SIVmac251 (98%) and SIVmacl42 (96%). It will now be possible to test which features of the viral sequence are critical molecular determinants for the pathogenesis of AIDS. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：1221 / 1231

页数：11

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