EPIDERMAL GROWTH-FACTOR RECEPTOR IN BREAST-CANCER - COMPARISON WITH NONMALIGNANT BREAST-TISSUE

被引：44
|
作者：
DITTADI, R
DONISI, PM
BRAZZALE, A
CAPPELLOZZA, L
BRUSCAGNIN, G
GION, M
机构：
[1] REG GEN HOSP VENICE,CTR STUDY BIOL MARKERS MALIGNANCY,ULSS 16,VENICE,ITALY
[2] REG GEN HOSP VENICE,SERV PATHOL ANAT,VENICE,ITALY
来源：
BRITISH JOURNAL OF CANCER | 1993年 / 67卷 / 01期
关键词：
D O I：
10.1038/bjc.1993.2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.
引用
收藏
页码：7 / 9
页数：3
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