ABERRANT ENERGY-LINKED REACTIONS IN MITOCHONDRIA ISOLATED FROM THE LIVERS OF SHEEP INFECTED WITH THE LIVER FLUKE FASCIOLA-HEPATICA

被引：4

作者：

RULE, CJ ^{[1
]}

HANISCH, MJE ^{[1
]}

BEHM, CA ^{[1
]}

BYGRAVE, FL ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,SCH LIFE SCI,DIV BIOCHEM & MOLEC BIOL,CANBERRA,ACT 2601,AUSTRALIA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1991年 / 21卷 / 03期

关键词：

FASCIOLA-HEPATICA; SHEEP; LIVER; MITOCHONDRIA; RESPIRATION;

D O I：

10.1016/0020-7519(91)90038-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Respiration by mitochondria isolated from the livers of sheep following infection up to 15 weeks with F. hepatica was measured with the respiratory substrates pyruvate (plus malate) and succinate in the absence and presence of ADP; the rates were compared with those obtained by mitochondria isolated from livers of uninfected sheep. It was found that respiration supported by both substrates in mitochondria isolated from the left lobe but not the middle lobe of 4-week infected sheep exhibited abnormalities such that the acceptor control ratios were only marginally above one. Some, but not total, recovery was seen in the later stages of infection. The aberrant respiratory behaviour is similar to that observed with infected rats.

引用

页码：353 / 355

页数：3

共 5 条

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[3] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[4] ABERRANT ENERGY-LINKED REACTIONS IN MITOCHONDRIA ISOLATED FROM THE LIVERS OF RATS INFECTED WITH THE LIVER FLUKE FASCIOLA-HEPATICA
RULE, CJ
BEHM, CA
BYGRAVE, FL
[J]. BIOCHEMICAL JOURNAL, 1989, 260 (02) : 517 - 523
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