BIOASSAY-DIRECTED FRACTIONATION OF MUTAGENIC PAH ATMOSPHERIC PHOTOOXIDATION PRODUCTS AND AMBIENT PARTICULATE EXTRACTS

被引：84

作者：

AREY, J ^{[1
]}

HARGER, WP ^{[1
]}

HELMIG, D ^{[1
]}

ATKINSON, R ^{[1
]}

机构：

[1] UNIV CALIF RIVERSIDE, DEPT SOIL & ENVIRONM SCI, RIVERSIDE, CA 92521 USA

来源：

MUTATION RESEARCH | 1992年 / 281卷 / 01期

关键词：

BIOASSAY-DIRECTED CHEMICAL ANALYSIS; CHEMICAL ANALYSIS; BIOASSAY-DIRECTED; PAH PHOTOOXIDATION PRODUCTS; ATMOSPHERIC MUTAGENS; NITROFLUORENES; NITROPHENANTHRENE LACTONES;

D O I：

10.1016/0165-7992(92)90038-J

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Simulated atmospheric gas-phase reactions of naphthalene, fluorene and phenanthrene have been carried out in an environmental chamber with bioassay-directed chemical analysis of the reaction products. Nitro-PAH were found to be the most significant mutagens formed from the reactions of naphthalene and fluorene. The mutagram (bar graph of mutagenic activity versus HPLC fraction) of the phenanthrene reaction products closely resembled that of an ambient air particulate extract with the most mutagenic activity being in a fraction more polar than that in which the nitro-PAH elute. Nitrophenanthrene lactones (nitro-6H-dibenzo[b,d]pyran-6-ones) were found to account for the observed activity of this polar fraction of the phenanthrene reaction products. It has been shown that the utilization of an environmental chamber with a known PAH-starting material and the ability to produce sufficient product for isomer-specific identifications of mutagens is a promising complement to bioassay-directed fractionation of ambient air particulate extracts.

引用

页码：67 / 76

页数：10

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