MOUSE BONE-MARROW RESPONSE TO LOW-DOSES OF WHOLE-BODY GAMMA-IRRADIATION - INDUCTION OF MICRONUCLEI

被引：39
作者：
DEVI, PU
SHARMA, ASKVS
机构：
[1] Department of Radiobiology, Kasturba Medical College, Manipal-576 119, Karnataka
来源：
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1990年 / 57卷 / 01期
关键词：
D O I：
10.1080/09553009014550371
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The induction of micronuclei in mouse bone marrow was studied after whole-body exposure to low doses of gamma radiation, ranging from 5 to 75 cGy. Micronuclei were scored at 10 and 30 h after irradiation. A linear dose response was obtained at both postirradiation times. However, the number of micronuclei per 100 nuclei was lower at 30 h than at 10 h, and the dose - response curve for the former had a shallower slope. When fitted to the αD + βD2 model, a negative β value was obtained. This could be due to division delay, combined with elimination of damaged cells by death at higher doses. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：97 / 101
页数：5
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