Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy: a review

被引：11
|
作者：
Shanmuganathan, Thayalini [1 ]
Girgis, Christian [2 ]
Lahooti, Hooshang [1 ]
Champion, Bernard [1 ]
Wall, Jack R. [1 ]
机构：
[1] Univ Sydney, Dept Med, Nepean Clin Sch, Nepean Hosp, South Block,5th Floor, Sydney, NSW 2751, Australia
[2] Univ Sydney, Westmead Millennium Inst, Dept Med, Sydney, NSW 2751, Australia
来源：
CLINICAL OPHTHALMOLOGY | 2015年 / 9卷
关键词：
ophthalmopathy; Graves' disease; thyroglobulin; thyroid peroxidase; TSH receptor; lymphocytes; autoantibodies;
D O I：
10.2147/OPTH.S88444
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves' hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation. Here, we review new evidence that supports a role of Tg and propose a new hypothesis based on the notion that Tg is targeted in the orbit leading to a complex cascade of reactions that leads to Graves' ophthalmopathy.
引用
收藏
页码：2271 / 2276
页数：6
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