4-AMINO-4-ARYLCYCLOHEXANONES AND THEIR DERIVATIVES, A NOVEL CLASS OF ANALGESICS .1. MODIFICATION OF THE ARYL RING

被引：22

作者：

LEDNICER, D ^{[1
]}

VONVOIGTLANDER, PF ^{[1
]}

EMMERT, DE ^{[1
]}

机构：

[1] UPJOHN CO,RES LABS,KALAMAZOO,MI 49001

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1980年 / 23卷 / 04期

关键词：

D O I：

10.1021/jm00178a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：424 / 430

页数：7

共 11 条

[1] SYNTHETIC ANALGESICS - STEREOCHEMICAL CONSIDERATIONS [J].

BECKETT, AH ;

CASY, AF .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1954, 6 (12) :986-1001

[2]

FINNEY DJ, 1952, STATISTICAL METHOD B

[3]

HAUSER CR, 1954, J ORG CHEM, V24, P46

[4] BUTYROPHENONES AS HYPOTENSIVE AGENTS - DERIVATIVES OF 4-ARYL-4-(HYDROXYMETHYL)CYCLOHEXYLAMINE [J].

LEDNICER, D ;

EMMERT, DE ;

RUDZIK, AD ;

GRAHAM, BE .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (06) :593-599

[5]

LEDNICER D, 1979, J MED CHEM, V22, P1157, DOI 10.1021/jm00196a001

[6] AXIALLY DISPOSED PHENYL GROUPS IN GEMINALLY SUBSTITUTED CYCLOHEXANES [J].

LEDNICER, D ;

DUCHAMP, DJ .

JOURNAL OF ORGANIC CHEMISTRY, 1974, 39 (15) :2311-2313

[7] PARTLY REDUCED BIPHENYLS AS CENTRAL NERVOUS-SYSTEM AGENTS .3. CIS- AND TRANS-4-ARYL-4-METHOXYCYCLOHEXYLAMINES [J].

LEDNICER, D ;

EMMERT, DE ;

LAHTI, R ;

RUDZIK, AD .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (11) :1251-1256

[8] STEREOCHEMICAL FACTORS AND RECEPTOR INTERACTIONS ASSOCIATED WITH NARCOTIC ANALGESICS [J].

PORTOGHE.PS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (09) :865-&

[9]

SCHAUMANN O., 1949, PHARMAZIE, V4, P364

[10]

SHIORI T, 1972, J AM CHEM SOC, V94, P6204

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