BIODEHALOGENATION . PATHWAY FOR TRANSHALOGENATION AND STEREOCHEMISTRY OF EPOXIDE FORMATION FROM HALOHYDRINS

被引：26

作者：

BARTNICKI, EW

CASTRO, CE

机构：

[1] Department of Nematology, University of California, California 92502, Riverside

来源：

BIOCHEMISTRY | 1969年 / 8卷 / 12期

关键词：

D O I：

10.1021/bi00840a003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A partially purified protein obtained from a Flavobacterium sp. exchanges the halogen atoms of α-halo epoxides. The process has been shown to be reversible and its path delineated. The conversion of epibromohydrin into epichlorohydrin via the route: epibromohydrin + chloride ⇌ 1-bromo-3-chloropropanol ⇌ epichlorohydrin + bromide is illustrative. The conversion of halohydrins into epoxides by the enzyme is a stereospecific trans process. © 1969, American Chemical Society. All rights reserved.

引用

页码：4677 / +

页数：1