ANALYSIS OF LIGAND-BINDING TO HEME-PROTEINS USING A FLUCTUATING PATH DESCRIPTION

被引：28
|
作者：
PANCHENKO, AR [1 ]
WANG, J [1 ]
NIENHAUS, GU [1 ]
WOLYNES, PG [1 ]
机构：
[1] UNIV ILLINOIS,SCH CHEM SCI,DEPT PHYS,URBANA,IL 61801
来源：
JOURNAL OF PHYSICAL CHEMISTRY | 1995年 / 99卷 / 22期
关键词：
D O I：
10.1021/j100022a049
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We use the dominant survival path approximation to treat in detail the CO-Mb rebinding process. We develop best-fit parameters which describe the distributed barriers and their relaxation and fluctuations. The results are in good agreement with the experimental data. The phenomenological parameters from the current model are compared with those from previous treatments. The limitations of the model and its comparison with more elaborate models taking into account taxonomic substates are discussed.
引用
收藏
页码：9278 / 9282
页数：5
相关论文
共 50 条
  • [1] DYNAMICS OF LIGAND-BINDING TO HEME-PROTEINS
    CASE, DA
    KARPLUS, M
    FEDERATION PROCEEDINGS, 1980, 39 (06) : 1648 - 1648
  • [2] DYNAMICS OF LIGAND-BINDING TO HEME-PROTEINS
    CASE, DA
    KARPLUS, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1979, (SEP): : 70 - &
  • [3] DYNAMICS OF LIGAND-BINDING TO HEME-PROTEINS
    CASE, DA
    KARPLUS, M
    JOURNAL OF MOLECULAR BIOLOGY, 1979, 132 (03) : 343 - 368
  • [4] LIGAND-BINDING TO HEME-PROTEINS - THE EFFECT OF LIGHT ON LIGAND-BINDING IN MYOGLOBIN
    NIENHAUS, GU
    MOURANT, JR
    CHU, K
    FRAUENFELDER, H
    BIOCHEMISTRY, 1994, 33 (45) : 13413 - 13430
  • [5] THE KINETIC INVERSION PROBLEM IN LIGAND-BINDING HEME-PROTEINS
    LERNER, DM
    AGMON, N
    ISRAEL JOURNAL OF CHEMISTRY, 1994, 34 (02) : 185 - 193
  • [6] MOLECULAR-DYNAMICS AND LIGAND-BINDING IN HEME-PROTEINS
    BIALEK, W
    GOLDSTEIN, RF
    BIOPHYSICAL JOURNAL, 1983, 41 (02) : A221 - A221
  • [7] LIGAND-BINDING TO HEME-PROTEINS - CONNECTION BETWEEN DYNAMICS AND FUNCTION
    STEINBACH, PJ
    ANSARI, A
    BERENDZEN, J
    BRAUNSTEIN, D
    CHU, K
    COWEN, BR
    EHRENSTEIN, D
    FRAUENFELDER, H
    JOHNSON, JB
    LAMB, DC
    LUCK, S
    MOURANT, JR
    NIENHAUS, GU
    ORMOS, P
    PHILIPP, R
    XIE, AH
    YOUNG, RD
    BIOCHEMISTRY, 1991, 30 (16) : 3988 - 4001
  • [8] CONTROL AND PH-DEPENDENCE OF LIGAND-BINDING TO HEME-PROTEINS
    DOSTER, W
    BEECE, D
    BOWNE, SF
    DIIORIO, EE
    EISENSTEIN, L
    FRAUENFELDER, H
    REINISCH, L
    SHYAMSUNDER, E
    WINTERHALTER, KH
    YUE, KT
    BIOCHEMISTRY, 1982, 21 (20) : 4831 - 4839
  • [9] LIGAND-BINDING TO HEME-PROTEINS .2. TRANSITIONS IN THE HEME POCKET OF MYOGLOBIN
    MOURANT, JR
    BRAUNSTEIN, DP
    CHU, K
    FRAUENFELDER, H
    NIENHAUS, GU
    ORMOS, P
    YOUNG, RD
    BIOPHYSICAL JOURNAL, 1993, 65 (04) : 1496 - 1507
  • [10] LIGAND-BINDING TO HEME-PROTEINS - RELEVANCE OF LOW-TEMPERATURE DATA
    ANSARI, A
    DIIORIO, EE
    DLOTT, DD
    FRAUENFELDER, H
    IBEN, IET
    LANGER, P
    RODER, H
    SAUKE, TB
    SHYAMSUNDER, E
    BIOCHEMISTRY, 1986, 25 (11) : 3139 - 3146
12345