ANTIBIOTIC-ASSOCIATED ACUTE VANISHING BILE-DUCT SYNDROME - A PATTERN ASSOCIATED WITH SEVERE, PROLONGED, INTRAHEPATIC CHOLESTASIS

被引：66
作者：
DAVIES, MH [1 ]
HARRISON, RF [1 ]
ELIAS, E [1 ]
HUBSCHER, SG [1 ]
机构：
[1] UNIV BIRMINGHAM,SCH MED,DEPT PATHOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
来源：
JOURNAL OF HEPATOLOGY | 1994年 / 20卷 / 01期
关键词：
DRUG REACTION; DUCTOPENIA; HEPATOTOXICITY; JAUNDICE;
D O I：
10.1016/S0168-8278(05)80476-3
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We report cases of amoxycillin- and flucloxacillin-induced liver damage associated with an acute vanishing bile duct syndrome. Ductopenia was present at the time of first liver biopsy, 3 weeks and 3 months after administration of the two drugs, respectively. Ductopenia apparently occurred as the primary lesion, with no evidence of accompanying portal tract inflammation. Subsequent biopsies showed a persistent paucity of ducts, accompanied by increasing features of chronic cholestasis. Biochemical dysfunction persists at 2 year's follow-up and late prognosis remains guarded. (C) Journal of Hepatology.
引用
收藏
页码：112 / 116
页数：5
相关论文
共 38 条
  • [1] HEPATIC DUCTULAR HYPOPLASIA ASSOCIATED WITH CHARACTERISTIC FACIES, VERTEBRAL MALFORMATIONS, RETARDED PHYSICAL, MENTAL AND SEXUAL DEVELOPMENT, AND CARDIAC MURMUR
    ALAGILLE, D
    ODIEVRE, M
    GAUTIER, M
    DOMMERGUES, JP
    [J]. JOURNAL OF PEDIATRICS, 1975, 86 (01) : 63 - 71
  • [2] INTRAHEPATIC CHOLESTASIS INDUCED BY AMOXICILLIN CLAVULANIC ACID (AUGMENTIN) - A REPORT ON 2 CASES
    ALEXANDER, P
    ROSKAMS, T
    VANSTEENBERGEN, W
    PEETERMANS, W
    DESMET, V
    YAP, SH
    [J]. ACTA CLINICA BELGICA, 1991, 46 (05): : 327 - 332
  • [3] CHRONIC CHOLESTASIS, PAUCITY OF BILE-DUCTS, RED-CELL APLASIA, AND THE STEVENS-JOHNSON SYNDROME - AN AMPICILLIN-ASSOCIATED CASE
    CAVANZO, FJ
    GARCIA, CF
    BOTERO, RC
    [J]. GASTROENTEROLOGY, 1990, 99 (03) : 854 - 856
  • [4] DRUG-INDUCED PROLONGED CHOLESTASIS IN ADULTS - A HISTOLOGICAL SEMIQUANTITATIVE STUDY DEMONSTRATING PROGRESSIVE DUCTOPENIA
    DEGOTT, C
    FELDMANN, G
    LARREY, D
    DURANDSCHNEIDER, AM
    GRANGE, D
    MACHAYEKHI, JP
    MOREAU, A
    POTET, F
    BENHAMOU, JP
    [J]. HEPATOLOGY, 1992, 15 (02) : 244 - 251
  • [5] AMOXYCILLIN CLAVULANIC ACID (AUGMENTIN)-INDUCED INTRAHEPATIC CHOLESTASIS
    DOWSETT, JF
    GILLOW, T
    HEAGERTY, A
    RADCLIFFE, M
    TOADI, R
    ISLE, I
    RUSSELL, RCG
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1989, 34 (08) : 1290 - 1293
  • [6] FERRARA JLM, 1991, NEW ENGL J MED, V324, P667
  • [7] GOLDFISCHER S, 1980, AM J PATHOL, V99, P715
  • [8] HORST DA, 1980, GASTROENTEROLOGY, V79, P550
  • [9] VANISHING BILE-DUCT SYNDROME FOLLOWING LIVER-TRANSPLANTATION - IS IT REVERSIBLE
    HUBSCHER, SG
    BUCKELS, JAC
    ELIAS, E
    MCMASTER, P
    NEUBERGER, J
    [J]. TRANSPLANTATION, 1991, 51 (05) : 1004 - 1010
  • [10] HUBSCHER SG, 1993, IN PRESS HEPATOLOGY, V17
1234