PROOXIDANT ROLE OF VITAMIN-E IN COPPER-INDUCED LIPID-PEROXIDATION

被引：78
作者：
MAIORINO, M [1 ]
ZAMBURLINI, A [1 ]
ROVERI, A [1 ]
URSINI, F [1 ]
机构：
[1] DEPT CHEM SCI & TECHNOL,I-33100 UDINE,ITALY
来源：
FEBS LETTERS | 1993年 / 330卷 / 02期
关键词：
VITAMIN-E; ALPHA-TOCOPHEROL; COPPER; PHOSPHOLIPID HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN; ATHEROSCLEROSIS;
D O I：
10.1016/0014-5793(93)80267-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When exposed to Cu2+, alpha-tocopherol, in detergent dispersion, is rapidly oxidised. Moreover, if phospholipids and traces of their hydroperoxide derivatives are included in these dispersions, Cu2+ initiates lipid peroxidation, the rate of which is dramatically stimulated by alpha-tocopherol. The observation that the rate of alpha-tocopherol consumption is identical in the absence and in the presence of lipids undergoing peroxidation, apparently rules out any antioxidant effect, These results are consistent with a prooxidant effect of vitamin E, mediated by its capability to reduce Cu2+ to Cu+ which, in tum, produces, from lipid hydroperoxides, the highly reactive alkoxyl radicals. Present data highlight the risk of misleading results in interpreting the significance of lags in peroxidation of LDL challenged with Cu2+.
引用
收藏
页码：174 / 176
页数：3
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