REACTIVITIES OF 20 ANTI-HUMAN MONOCLONAL-ANTIBODIES WITH LEUKOCYTES FROM 10 DIFFERENT ANIMAL SPECIES

被引：107

作者：

JACOBSEN, CN ^{[1
]}

AASTED, B ^{[1
]}

BROE, MK ^{[1
]}

PETERSEN, JL ^{[1
]}

机构：

[1] DAKO AS,DK-2600 GLOSTRUP,DENMARK

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1993年 / 39卷 / 04期

关键词：

D O I：

10.1016/0165-2427(93)90075-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twenty commercially available monoclonal antibodies (mAbs) raised against various human leucocyte surface antigens were tested on lymphocytes, monocytes and granulocytes from horse, pig, cow, sheep, goat, dog, mink, rabbit, rhesus monkey as well as man. Eight antibodies reacted with leucocytes from some of the animals. These were the antibodies against CD2, CD4, CD5, CD8, CD14, CD18, HLA-DR, and the HLA-ABC antigen. The CD18 antibody reacted with lymphocytes, monocytes and granulocytes from all animals tested except goat. The CD14 antibody reacted viiith monocytes from pig, cow, sheep, goat, dog, mink, rabbit and monkey and with granulocytes from pig and rabbit. The anti-HLA-ABC reacted with leucocytes from monkey and cow. Finally, the CD2, CD4, CD5 and CD8 antibodies reacted with leucocytes from monkey only.

引用

页码：461 / 466

页数：6

共 6 条

[1] REACTIVITY OF 11 ANTI-HUMAN LEUKOCYTE MONOCLONAL-ANTIBODIES WITH LYMPHOCYTES FROM SEVERAL DOMESTIC-ANIMALS [J].