RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE CAN ATTENUATE ISCHEMIC NEURONAL DAMAGE IN GERBILS

被引：33
作者：
TAGAYA, M
MATSUMOTO, M
KITAGAWA, K
NIINOBE, M
OHTSUKI, T
HATA, R
OGAWA, S
HANDA, N
MIKOSHIBA, K
KAMADA, T
机构：
[1] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 1,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
[2] OSAKA UNIV,INST PROT RES,DIV REGULAT MACROMOLEC FUNCT,SUITA,OSAKA 565,JAPAN
来源：
LIFE SCIENCES | 1992年 / 51卷 / 04期
关键词：
D O I：
10.1016/0024-3205(92)90083-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.
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页码：253 / 259
页数：7
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