PEPTIDE SELECTION BY MHC CLASS-I MOLECULES

被引:275
作者
SCHUMACHER, TNM [1 ]
DEBRUIJN, MLH [1 ]
VERNIE, LN [1 ]
KAST, WM [1 ]
MELIEF, CJM [1 ]
NEEFJES, JJ [1 ]
PLOEGH, HL [1 ]
机构
[1] NETHERLANDS CANC INST,DEPT IMMUNOL,1066 CX AMSTERDAM,NETHERLANDS
关键词
D O I
10.1038/350703a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
SYNTHETIC peptides have been used to sensitize target cells and thereby screen for epitopes recognized by T cells 1-7. Most epitopes of cytotoxic T lymphocytes can be mimicked by synthetic peptides of 12-15 amino acids 8. Although in specific cases, truncations of peptides improves sensitization of target cells 8,9, no optimum length for binding to major histocompatibility complex (MHC) class I molecules has been defined. We have now analysed synthetic peptide captured by empty MHC class I molecules of the mutant cell line RMA-S. We found that class I molecules preferentially bound short peptides (nine amino acids) and selectively bound these peptides even when they were a minor component in a mixture of longer peptides. These results may help to explain the difference in size restriction of T-cell epitopes between experiments with synthetic peptides and those with naturally processed peptides 10-12.
引用
收藏
页码:703 / 706
页数:4
相关论文
共 26 条
[1]  
BJORKMAN PJ, 1990, REV BIOCH, V59, P253
[2]   ANTIGEN PRESENTATION - NATURALLY PROCESSED PEPTIDES [J].
ELLIOTT, T ;
TOWNSEND, A ;
CERUNDOLO, V .
NATURE, 1990, 348 (6298) :195-197
[3]   CYTOTOXIC LYMPHOCYTES-T RECOGNIZE A FRAGMENT OF INFLUENZA-VIRUS MATRIX PROTEIN IN ASSOCIATION WITH HLA-A2 [J].
GOTCH, F ;
ROTHBARD, J ;
HOWLAND, K ;
TOWNSEND, A ;
MCMICHAEL, A .
NATURE, 1987, 326 (6116) :881-881
[4]  
GOTCH F, 1988, J EXP MED, V186, P2057
[5]   ISOLATION OF 12 MONOCLONAL ANTIBODIES AGAINST IA AND H-2-ANTIGENS - SEROLOGICAL CHARACTERIZATION AND REACTIVITY WITH LYMPHOCYTE-B AND LYMPHOCYTE-T [J].
HAMMERLING, GJ ;
HAMMERLING, U ;
LEMKE, H .
IMMUNOGENETICS, 1979, 8 (5-6) :433-445
[6]   PREPARATION OF IODINE-131 LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC ACTIVITY [J].
HUNTER, WM ;
GREENWOOD, FC .
NATURE, 1962, 194 (4827) :495-&
[7]   SELECTIVE REJECTION OF H-2-DEFICIENT LYMPHOMA VARIANTS SUGGESTS ALTERNATIVE IMMUNE DEFENSE STRATEGY [J].
KARRE, K ;
LJUNGGREN, HG ;
PIONTEK, G ;
KIESSLING, R .
NATURE, 1986, 319 (6055) :675-678
[8]   ERADICATION OF ADENOVIRUS E1-INDUCED TUMORS BY E1A-SPECIFIC CYTO-TOXIC LYMPHOCYTES-T [J].
KAST, WM ;
OFFRINGA, R ;
PETERS, PJ ;
VOORDOUW, AC ;
MELOEN, RH ;
VANDEREB, AJ ;
MELIEF, CJM .
CELL, 1989, 59 (04) :603-614
[9]   COOPERATION BETWEEN CYTOTOXIC AND HELPER LYMPHOCYTES-T IN PROTECTION AGAINST LETHAL SENDAI VIRUS-INFECTION - PROTECTION BY T-CELLS IS MHC-RESTRICTED AND MHC-REGULATED - A MODEL FOR MHC-DISEASE ASSOCIATIONS [J].
KAST, WM ;
BRONKHORST, AM ;
DEWAAL, LP ;
MELIEF, CJM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (03) :723-738
[10]  
KAST WM, IN PRESS P NATN ACAD