5-METHYLURAPIDIL MAY DISCRIMINATE BETWEEN ALPHA-1-ADRENOCEPTORS WITH A HIGH-AFFINITY FOR WB4101 IN RAT LUNG

被引：15

作者：

HIRAMATSU, Y

MURAOKA, R

KIGOSHI, S

MURAMATSU, I

机构：

[1] FUKUI MED SCH,DEPT SURG 2,FUKUI 91011,JAPAN

[2] FUKUI MED SCH,DEPT PHARMACOL,FUKUI 91011,JAPAN

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 105卷 / 01期

关键词：

ALPHA-1-ADRENOCEPTOR SUBTYPE; 5-METHYLURAPIDIL; WB4101; RAT LUNG;

D O I：

10.1111/j.1476-5381.1992.tb14200.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The alpha(1)-adrenoceptors of rat lung with a high affinity for [H-3]-prazosin were subdivided into two populations (high and low affinity sites) by WB4101 and 5-methylurapidil but the proportions were different between both drugs. After pretreatment with chlorethylclonidine, WB4101 recognized only high affinity sites, while 5-methylurapidil still detected high and low affinity sites. These results indicate that alpha(1)-adrenoceptors with a high affinity for WB4101 are not homogeneous in the rat lung, suggesting the possible existence of a new alpha(1)-adrenoceptor subtype in addition to alpha(1A) and alpha(1B) subtypes.

引用

页码：6 / 7

页数：2