SULFONYLUREA ENHANCES INSULIN-INDUCED ACETYL COENZYME-A CARBOXYLASE ACTIVITY IN RAT ADIPOCYTES

被引：8

作者：

MATSUDA, M ^{[1
]}

KAKU, K ^{[1
]}

AOKI, M ^{[1
]}

INOUE, H ^{[1
]}

KANEKO, T ^{[1
]}

机构：

[1] YAMAGUCHI UNIV,SCH MED,DEPT INTERNAL MED 3,1144 KOGUSHI,UBE,YAMAGUCHI 755,JAPAN

来源：

HORMONE AND METABOLIC RESEARCH | 1991年 / 23卷 / 05期

关键词：

SULFONYLUREA; ACETYL-COA CARBOXYLASE; ADIPOCYTES;

D O I：

10.1055/s-2007-1003655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of sulfonylurea on the activity of acetyl-coenzyme A carboxylase, a rate limiting enzyme of lipogenesis, was investigated using isolated rat adipocytes. Insulin significantly increased the enzyme activity by 170% of the control level, while glucagon and epinephrine decreased the activity of the enzyme by 53% and 64% of the control, respectively. In the presence of tolbutamide (10(-3) M) or glibenclamide (10(-6) M), a significant potentiation of insulin action was found in adipocytes. In addition, sulfonylurea restored the activity of acetyl-CoA carboxylase reduced by glucagon or epinephrine to the control level. Sulfonylurea enhancement of the acetyl-CoA carboxylase activity may offer one possible explanation for a mechanism of antilipolytic action of the drug in adipocytes.

引用

页码：209 / 212

页数：4

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