SYNTHESES AND NMR CHARACTERIZATION OF CHELATED HEME MODELS OF HEMOPROTEINS

被引：145
作者：
TRAYLOR, TG
CHANG, CK
GEIBEL, J
BERZINIS, A
MINCEY, T
CANNON, J
机构：
[1] Department of Chemistry, D-006, University of California, San Diego, La Jolla
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1979年 / 101卷 / 22期
关键词：
D O I：
10.1021/ja00516a038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Convenient syntheses of “chelated heme” compounds from naturally occurring hemes are described. NMR studies of the carbon monoxide complex of chelated protoheme serve to characterize this model compound in solution. Chelated protoheme, having a “proximal” imidazole covalently attached, displays spectra and kinetics and equilibria of reaction with dioxygen and carbon monoxide that are similar to those of R-state hemoglobin, making chelated protoheme unique among model compounds. © 1979, American Chemical Society. All rights reserved.
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页码：6716 / 6731
页数：16
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