Transcriptional regulation of the human telomerase reverse transcriptase New insights

被引：6
|
作者：
Chebel, Amel [1 ]
Ffrench, Martine [1 ,2 ]
机构：
[1] Univ Lyon 1, CNRS UMR 5239, ENS UCB HCL, Fac Lyon Sud, Oullins, France
[2] Hosp Civils Lyon, Lab Hematol, Pierre Benite, France
来源：
TRANSCRIPTION-AUSTIN | 2010年 / 1卷 / 01期
关键词：
hTERT; NFAT; cell stimulation; tumorigenesis; immunosuppression;
D O I：
10.4161/trns.1.1.12062
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription, suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments, explains the link between hTERT expression and cell stimulation and offers new insights for therapeutic developments.
引用
收藏
页码：27 / 31
页数：5
相关论文
共 50 条
  • [1] Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
    Khattar, Ekta
    Tergaonkar, Vinay
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2017, 5
  • [2] Regulation of the human telomerase reverse transcriptase gene
    Ducrest, AL
    Szutorisz, H
    Lingner, J
    Nabholz, M
    ONCOGENE, 2002, 21 (04) : 541 - 552
  • [3] Regulation of the human telomerase reverse transcriptase gene
    Anne-Lyse Ducrest
    Henrietta Szutorisz
    Joachim Lingner
    Markus Nabholz
    Oncogene, 2002, 21 : 541 - 552
  • [4] Human Specific Regulation of the Telomerase Reverse Transcriptase Gene
    Zhang, Fan
    Cheng, De
    Wang, Shuwen
    Zhu, Jiyue
    GENES, 2016, 7 (07)
  • [5] Transcriptional regulation mechanisms of telomerase reverse transcriptase gene responsible for ubiquitous expression of telomerase in mouse
    Fujiki, T
    Katakura, Y
    Miura, T
    Kotake, Y
    Yoshizaki, K
    Shirahata, S
    ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 13, 2003, : 329 - 333
  • [6] The telomerase reverse transcriptase: components and regulation
    Nugent, CI
    Lundblad, V
    GENES & DEVELOPMENT, 1998, 12 (08) : 1073 - 1085
  • [7] The HBZ as a cofactor in the transcriptional upregulation of the human telomerase reverse transcriptase gene
    Kuhlmann, Anne-Sophie
    Gazzolo, Louis
    Castellazzi, Marc
    Mesnard, Jean-Michel
    Duc Dodon, Madeleine
    Duc Dodon, Madeleine
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (04) : 587 - 587
  • [8] Posttranscriptional regulation of telomerase reverse transcriptase in Human T cells
    Streater, Courtney
    An, Jie
    Weng, Nan Ping
    FASEB JOURNAL, 2012, 26
  • [9] Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
    Ramlee, Muhammad Khairul
    Wang, Jing
    Toh, Wei Xun
    Li, Shang
    GENES, 2016, 7 (08):
  • [10] Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT)
    Qi, Dong-Lai
    Ohhira, Takahito
    Oshimura, Mitsuo
    Kugoh, Hiroyuki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 398 (04) : 695 - 701
12345