Hemolytic Disease of the Newborn Caused by Anti-Wright (Anti-Wr(a)): Case Report and Review of the Literature

被引：7

作者：

Squires, Amanda ^{[1
]}

Nasef, Nehad ^{[2
,3
,4
,5
]}

Lin, Yulia ^{[6
,7
]}

Callum, Jeannie ^{[8
]}

Khadawardi, Emad M. ^{[9
,10
,11
]}

Drolet, Christine ^{[12
]}

Core, David ^{[13
]}

Simmons, Brian ^{[14
,15
,16
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, NICU, Toronto, ON, Canada

[2] Mansoura Univ, Neonatal Intens Care Unit, Children Hosp, Mansoura, Dakahlia, Egypt

[3] Univ Mansoura, Pediat, Fac Med, Dakahlia, Egypt

[4] Hosp Sick Children, Neonatal Peri Natal Med, Toronto, ON, Canada

[5] Sunnybrook Hlth Sci Ctr, Neonataol, Neonatal Intens Care Unit, Toronto, ON, Canada

[6] Sunnybrook Hlth Sci Ctr, Dept Clin Pathol, Toronto, ON, Canada

[7] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[8] Sunnybrook Hlth Sci Center, Transfus Med Dept, Toronto, ON, Canada

[9] King Faisal Specialist Hosp & Res Ctr, Neonatol, Fellowship Training Program Neonatal Perinatal Me, Dept Pediat, Riyadh 11211, Saudi Arabia

[10] King Faisal Specialist Hosp & Res Ctr, Fellowship Training Program Neonatal Perinatal Me, Dept Pediat, Riyadh 11211, Saudi Arabia

[11] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[12] Univ Laval, CHUL, CME, Quebec City, PQ, Canada

[13] Sunnybrook Hlth Sci Ctr, Transfus Med, Toronto, ON, Canada

[14] Univ Toronto, Dept Paediat, Fac Med, Toronto, ON, Canada

[15] Royal Coll Phys & Surg, Board Examiners Neonatal Perinatal Med NPM, Toronto, ON, Canada

[16] Univ Toronto, Standardized Patient Program, Toronto, ON, Canada

来源：

NEONATAL NETWORK | 2012年 / 31卷 / 02期

关键词：

D O I：

10.1891/0730-0832.31.2.69

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

Antibodies to red cell antigens that are found at low frequency in the general population are rare causes of hemolytic disease of the newborn. To understand how to detect these cases, we provide a basic review of routine antenatal maternal antibody testing and report a case of a neonate with severe HDN caused by anti-Wright (anti-Wr(a)), successfully managed with transfusion, phototherapy, and high-dose intravenous immunoglobulin. When hemolysis in a newborn is suspected in the absence of major blood group incompatibility or commonly detected maternal red cell antibodies, a direct antiglobulin test should be performed. A positive DAT should alert the clinician to the presence of maternal antibodies against low-incidence antigens. Antibodies to the Wr(a) antigen are one such rare cause of HDN.

引用

页码：69 / 80

页数：12

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