DE-NOVO ACUTE MYELOID-LEUKEMIA IN PATIENTS WITH CROHNS-DISEASE

被引：0
作者：
DOMBRET, H
MAROLLEAU, JP
机构：
来源：
NOUVELLE REVUE FRANCAISE D HEMATOLOGIE | 1995年 / 37卷 / 03期
关键词：
CROHNS DISEASE; ACUTE MYELOID LEUKEMIA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Crohn's disease (CD) has been occasionally reported to be associated with myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML). From October 1991 to June 1993, four AML patients with a previous history of CD but no history of MDS were referred to our institution. Three presented AML with a monoblastic proliferation (one AML4 and two AML5). Cytogenetic analysis revealed a normal karyotype in two patients, an inv(16) in another and a del(11)(q24-25) in the fourth. Interestingly, the three patients with AML4/AMLS had not received high doses of immunosuppressive agents, prior CD therapy ranging from 1 to 4 months sulfasalazine with additional azathioprine in one case.
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页码：193 / 196
页数：4
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