NO TP53 MUTATIONS IN NEUROBLASTOMAS DETECTED BY PCR-SSCP ANALYSIS

被引：29
|
作者：
CASTRESANA, JS
BELLO, ML
REY, JA
NEBREDA, P
QUEIZAN, A
GARCIAMIGUEL, P
PESTANA, A
机构：
[1] HOSP INFANTIL LA PAZ,DEPT PEDIAT SURG,MADRID,SPAIN
[2] HOSP INFANTIL LA PAZ,DEPT PEDIAT ONCOL,MADRID,SPAIN
来源：
GENES CHROMOSOMES & CANCER | 1994年 / 10卷 / 02期
关键词：
D O I：
10.1002/gcc.2870100209
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have analysed 29 neuroblastomas for TP53 mutations in exons 5 to 8 by means of the polymerase chain reaction in combination with the single-strand conformation polymorphism technique. We could not detect any mutation. These results indicate that, in contrast to the majority of tumors so far studied, TP53 mutations do not seem to be important for the development of neuroblastomas. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码：136 / 138
页数：3
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