3 INHIBITORS OF TYPE-1 HUMAN-IMMUNODEFICIENCY-VIRUS LONG TERMINAL REPEAT-DIRECTED GENE-EXPRESSION AND VIRUS-REPLICATION

被引：205
|
作者：
LI, CJ
ZHANG, LJ
DEZUBE, BJ
CRUMPACKER, CS
PARDEE, AB
机构：
[1] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV INFECT DIS,BOSTON,MA 02215
[2] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV HEMATOL ONCOL,BOSTON,MA 02215
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 05期
关键词：
D O I：
10.1073/pnas.90.5.1839
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Transcription of type 1 human immunodeficiency virus (HIV-1) provirus is governed by the viral long terminal repeat (LTR). Drugs can block HIV-1 replication by inhibiting activity of its LTR. We report that topotecan, beta-lapachone, and curcumin are potent and selective inhibitors of HIV-1 LTR-directed gene expression, at concentrations that have minor effects on cells. At these concentrations, each drug inhibited p24 antigen production in cells either acutely or chronically infected with HIV-1. Their target is transcriptional function of the LTR.
引用
收藏
页码：1839 / 1842
页数：4
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