HUMAN PARVOVIRUS-B19 INFECTION IN HEMOPHILIACS 1ST INFUSED WITH 2 HIGH-PURITY, VIRALLY ATTENUATED FACTOR-VIII CONCENTRATES

被引：149
作者：
AZZI, A
CIAPPI, S
ZAKVRZEWSKA, K
MORFINI, M
MARIANI, G
MANNUCCI, PM
机构：
[1] UNIV FLORENCE,INST MICROBIOL,I-50121 FLORENCE,ITALY
[2] UNIV HOSP FLORENCE,DEPT HEMATOL,FLORENCE,ITALY
[3] UNIV HOSP FLORENCE,CTR HEMOPHILIA,FLORENCE,ITALY
[4] UNIV ROME,DEPT HUMAN BIOPATHOL,I-00100 ROME,ITALY
[5] MAGGIORE HOSP,INST RICOVERO & CURA CARATTRE SCI,INST INTERNAL MED,MILAN,ITALY
[6] MAGGIORE HOSP,A BIANCHI BONOMI HEMOPHILIA & THROMBOSIS CTR,MILAN,ITALY
[7] UNIV MILAN,I-20122 MILAN,ITALY
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1992年 / 39卷 / 03期
关键词：
COAGULATION FACTOR CONCENTRATES; VIRUCIDAL METHODS; ANTI-B19;
D O I：
10.1002/ajh.2830390315
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human parvovirus B19 can be transmitted by coagulation factor concentrates and is highly resistant to virucidal methods. To evaluate whether the additional removal of virus by chromatographic methods during the manufacture of high-purity concentrates reduces the risk of B19 transmission, we have prospectively evaluated the rate of anti-B19 seroconversion in two groups of susceptible (anti-B19 negative) hemophiliacs infused with high-purity, heated (pasteurized) or solvent-detergent-treated factor VIII concentrates. Both products infected a relatively high proportion of patients (nine of 20).
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收藏
页码：228 / 230
页数：3
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