ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA IN SNEDDON-WILKINSON SUBCORNEAL PUSTULAR DERMATOSIS - A MODEL OF NEUTROPHIL PRIMING INVIVO

被引：42

作者：

GROB, JJ ^{[1
]}

MEGE, JL ^{[1
]}

CAPO, C ^{[1
]}

JANCOVICCI, E ^{[1
]}

FOURNERIE, JR ^{[1
]}

BONGRAND, P ^{[1
]}

BONERANDI, JJ ^{[1
]}

机构：

[1] HOP ST MARGUERITE,IMMUNOL LAB,MARSEILLE,FRANCE

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1991年 / 25卷 / 05期

关键词：

D O I：

10.1016/0190-9622(91)70290-I

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids. A study of neutrophils from both blood and pustules was carried out before and during treatment. Levels of tumor necrosis factor-alpha were measured in serum, pustules, content, and supernatant of monocytes. The results suggest that a hyperactivation of neutrophils in the skin is due at least partly to excessive production of tumor necrosis factor-a.

引用

页码：944 / 947

页数：4

共 15 条

[1] THE BIOLOGY OF CACHECTIN/TNF - A PRIMARY MEDIATOR OF THE HOST RESPONSE [J].