POSSIBLE INVOLVEMENT OF A CHLORIDE CONDUCTANCE IN THE TRANSIENT OUTWARD CURRENT OF WHOLE-CELL VOLTAGE-CLAMPED FERRET VENTRICULAR MYOCYTES

被引：11
作者：
BOURON, A [1 ]
POTREAU, D [1 ]
RAYMOND, G [1 ]
机构：
[1] UNIV POITIERS,GEN PHYSIOL LAB,CNRS,URA 290,40 AVE RECTEUR PINEAU,F-86022 POITIERS,FRANCE
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1991年 / 419卷 / 05期
关键词：
CHLORIDE CONDUCTANCE; TRANSIENT OUTWARD CURRENT; CARDIAC CELLS; WHOLE CELL PATCH CLAMP;
D O I：
10.1007/BF00370801
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The transient outward current was studied, using the whole-cell patch-clamp technique, in isolated ventricular cells from the ferret heart. In the presence of 4-aminopyridine and cadmium chloride which respectively blocked the Ca-insensitive and the Ca-dependent outward currents, a residual transient outward current was observed in about 30% of the cells tested. This current was suppressed in external hypochloride solution, completely inhibited by SITS (3mM) and reversed at the equilibrium potential for chloride ions. This suggests the presence of a chloride permeability which could contribute to the repolarization phase of the cardiac action potential.
引用
收藏
页码：534 / 536
页数：3
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