PATIENTS WITH IDIOPATHIC CARDIOMYOPATHY BELONG TO THE SAME MITOCHONDRIAL-DNA GENE FAMILY OF PARKINSONS-DISEASE AND MITOCHONDRIAL ENCEPHALOMYOPATHY

被引：108

作者：

OZAWA, T

TANAKA, M

SUGIYAMA, S

INO, H

OHNO, K

HATTORI, K

OHBAYASHI, T

ITO, T

DEGUCHI, H

KAWAMURA, K

NAKANE, Y

HASHIBA, K

机构：

[1] NAGOYA UNIV,FAC MED,DEPT INTERNAL MED,NAGOYA,AICHI 466,JAPAN

[2] OSAKA MED COLL,DEPT INTERNAL MED,TAKATSUKI,OSAKA 569,JAPAN

[3] NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED,NAGASAKI 852,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)92014-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comparison of total mitochondrial DNA sequences of patients with idiopathic (delated or hypertrophic) cardiomyopathy with those of patients with Parkinson's disease and mitochondrial encephalomyopathies revealed distinct clustering of point mutations among patients. Furthermore, an inverse relation was found between the total number of base-substitution and life span of the patients. Among point mutations found in each patient, sequentially diverged six clusters consisting of 14, 10, 7, 1, 2, and 3 mutations, respectively, were detected. Five sub-clusters consisting of 2, 2, 11, 1, and 1 mutations, respectively, were detected. From each cluster, the patient's unique mutations were diverged with three types of the mutations specific for the disease. The divergence allowed construction of a phylogenetic tree which clearly indicated that patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathies. © 1991.

引用

页码：518 / 525

页数：8

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