STRUCTURE OF PREUROPORPHYRINOGEN - EXPLORATION OF AN ENZYME MECHANISM BY C-13 AND N-15 NMR-SPECTROSCOPY

被引：37

作者：

BURTON, G ^{[1
]}

NORDLOV, H ^{[1
]}

HOSOZAWA, S ^{[1
]}

MATSUMOTO, H ^{[1
]}

JORDAN, PM ^{[1
]}

FAGERNESS, PE ^{[1
]}

PRYDE, LM ^{[1
]}

SCOTT, AI ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1979年 / 101卷 / 11期

关键词：

D O I：

10.1021/ja00505a046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We recently described1.2 the discovery of preuroporphyrinogen (preurogen), a labile ([formula omitted] = 4 min), tetrapyrrolic intermediate in the conversion of porphobilinogen (PBG, 1) to uroporphyrinogen (uro'gen) I (2) catalyzed by the enzyme PBG deaminase. The importance of this substance, released from the enzyme and observed as a l3C-enriched species at pH 8.5, resides in its proven role2 as the first recognized substrate for the second enzyme of tetrapyrrole biosynthesis, uro'gen 111 cosynthetase, which has hitherto been considered as a syner. © 1979, American Chemical Society. All rights reserved.

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页码：3114 / 3116

页数：3

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