DYNAMIC BEHAVIOR OF CHEMOSTAT SUBJECT TO SUBSTRATE INHIBITION

被引:159
作者
YANO, T
KOGA, S
机构
[1] Department of Agricultural Chemistry, University of Tokyo, Tokyo
[2] Institute of Applied Microbiology, University of Tokyo, Tokyo
关键词
D O I
10.1002/bit.260110204
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A theoretical study was made on the dynamic behavior of a single‐vessel continuous fermentation subject to a growth inhibition at, high concentration of the rate limiting substrate. Phase plane plotting and stability analysis showed three steady states to exist; namely, a “washout”; state, a nontrivial stable state, and an unstable state. Whether the system attains a nontrivial steady state or is to be washed‐out depends upon the initial values of the cell and/or substrate concentration(s). Since this property is a characteristic feature of the present system, an experimental procedure was suggested to insure a stable operation in practice. Copyright © 1969 John Wiley & Sons, Inc.
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页码:139 / &
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