LONG-TERM SURVIVAL OF XENOGENEIC PANCREATIC-ISLET GRAFTS INDUCED BY CTLA4IG

被引：1147

作者：

LENSCHOW, DJ

ZENG, YJ

THISTLETHWAITE, JR

MONTAG, A

BRADY, W

GIBSON, MG

LINSLEY, PS

BLUESTONE, JA

机构：

[1] UNIV CHICAGO,BEN MAY INST,CHICAGO,IL 60637

[2] UNIV CHICAGO,COMM IMMUNOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,DEPT SURG,CHICAGO,IL 60637

[4] UNIV CHICAGO,DEPT PATHOL,CHICAGO,IL 60637

[5] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,SEATTLE,WA 98121

来源：

SCIENCE | 1992年 / 257卷 / 5071期

关键词：

D O I：

10.1126/science.1323143

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antigen-specific T cell activation depends on T cell receptor-ligand interaction and co-stimulatory signals generated when accessory molecules bind to their ligands, such as CD28 to the B7 (also called BB1) molecule. A soluble fusion protein of human CTLA-4 (a protein homologous to CD28) and the immunoglobulin (Ig) G1 Fc region (CTLA4Ig) binds to human and murine B7 with high avidity and blocks T cell activation in vitro. CTLA4Ig therapy blocked human pancreatic islet rejection in mice by directly affecting T cell recognition of B7+ antigen-presenting cells. In addition, CTLA4Ig induced long-term, donor-specific tolerance, which may have applications to human organic transplantation.

引用

收藏

页码：789 / 792

页数：4

相关论文

共 50 条

[41] METHOD OF PANCREATIC-ISLET GRAFT PREPARATION ALLOWING SUCCESSFUL LONG-TERM FUNCTION [J].

GRIFFIN, SM ;

GUY, AJ ;

ALDERSON, D ;

FARNDON, JR .

BRITISH JOURNAL OF SURGERY, 1986, 73 (11) :935-935

[42] CTLA4Ig induces longterm cardiac allograft survival in the absence of interleukin-4. [J].

Lakkis, FG ;

Konieczny, BT ;

Lowry, RP ;

Linsley, PS ;

Alexander, DZ ;

Pearson, TC ;

Larsen, CP .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09) :A3204-A3204

[43] LOCAL CTLA4LG SYNERGIZES WITH ONE-DOSE ANTI-LFA-1 TO ACHIEVE LONG-TERM ACCEPTANCE OF PANCREATIC-ISLET ALLOGRAFTS [J].

CHAHINE, AA ;

YU, M ;

MCKERNAN, M ;

STOECKERT, C ;

LINSLEY, PS ;

LAU, HT .

TRANSPLANTATION PROCEEDINGS, 1994, 26 (06) :3296-3296

[44] Effect of Conversion to CTLA4Ig on Tacrolimus-Induced Diabetic Rats [J].

Jin, Long ;

Lim, Sun Woo ;

Jin, Jian ;

Luo, Kang ;

Ko, Eun Jeong ;

Chung, Byung Ha ;

Lin, Hong Li ;

Yang, Chul Woo .

TRANSPLANTATION, 2018, 102 (04) :E137-E146

[45] Long-term Graft Acceptance in Rat Heart Transplantation by CTLA4Ig Gene Transfection Combined with FTY720 Treatment [J].

Masanao Ohba ;

Xiao-Kang Li ;

Yusuke Kita ;

Shin Enosawa ;

Naoko Funeshima ;

Haruko Nagai ;

Hui-qi Zhang ;

Torayuki Okuyama ;

Shohei Ogoshi ;

Shiro Sasaguri ;

Hiroshi Amemiya ;

Seiichi Suzuki .

World Journal of Surgery, 2001, 25 :391-398

[46] Long-term graft acceptance in rat heart transplantation by CTLA4Ig gene transfection combined with FTY720 treatment [J].

Ohba, M ;

Li, XK ;

Kita, Y ;

Enosawa, S ;

Funeshima, N ;

Nagai, H ;

Zhang, HQ ;

Okuyama, T ;

Ogoshi, S ;

Sasaguri, S ;

Amemiya, H ;

Suzuki, S .

WORLD JOURNAL OF SURGERY, 2001, 25 (04) :391-398

[47] Bicistronic adenovirus-mediated gene transfer of CTLA4Ig gene and CD40Ig gene result in indefinite survival of islet xenograft [J].

Jin, YZ ;

Xie, SS .

TRANSPLANTATION PROCEEDINGS, 2003, 35 (08) :3165-3166

[48] Long-term survival of cardiac allografts induced by cyclophosphamide combined with CTLA4Ig-gene transfer mediated by adenoviral vector [J].

Wang, G. M. ;

Ma, J. B. ;

Jin, Y. Z. ;

Feng, Y. G. ;

Hao, J. ;

Gao, X. ;

Xie, S. S. .

TRANSPLANTATION PROCEEDINGS, 2006, 38 (09) :3043-3045

[49] LONG-TERM NORMOGLYCEMIA IN PANCREATECTOMIZED DOGS FOLLOWING PANCREATIC-ISLET ALLOTRANSPLANTATION AND CYCLOSPORINE IMMUNOSUPPRESSION [J].

KNETEMAN, NM ;

ALDERSON, D ;

SCHARP, DW .

TRANSPLANTATION, 1987, 44 (05) :595-599

[50] CYCLOSPORINE SUPPRESSES IMMUNE-MEDIATED PANCREATIC-ISLET ALLOGRAFT PRIMARY NONFUNCTION AND ENHANCES LONG-TERM FUNCTIONAL SURVIVAL [J].

KAUFMAN, DB ;

RABE, FL ;

STOCK, PG ;

VANDERVLIET, JA ;

PLATT, J ;

SUTHERLAND, DER .

TRANSPLANTATION PROCEEDINGS, 1988, 20 (03) :426-430

← 1 2 3 4 5 →